Journal Guide

Endocrinology and Metabolism publishes original, mechanistic studies on the physiology of endocrine and metabolic systems. Molecular, subcellular, and cellular studies in whole animals or humans will be considered. Specific themes include, but are not limited to, mechanisms of hormone and growth factor action; regulation of metabolism and energy balance; integrative organ cross talk; paracrine and autocrine control of endocrine cell performance; function and activation of hormone receptors; endocrine or metabolic control of channels, transporters and membrane function; differentiation of endocrine and reproductive cell function; temporal analysis of hormone secretion and metabolism; and mathematical/kinetic modeling and analysis of hormone action or metabolism. Novel molecular, immunological, or biophysical studies of hormone action are also welcome.

Advances in Physiology Education promotes and disseminates educational scholarship in order to enhance teaching and learning of physiology, neuroscience and pathophysiology. The journal publishes peer-reviewed descriptions of innovations that improve teaching in the classroom and laboratory, essays on education, and review articles based on our current understanding of physiological mechanisms. Submissions that evaluate new technologies for teaching and research, and educational pedagogy, are especially welcome. The audience for the journal includes educators at all levels: K-12, undergraduate, graduate, and professional programs.

The American Journal of Physiology-Gastrointestinal and Liver Physiology publishes original articles pertaining to all aspects of research involving normal or abnormal function of the gastrointestinal tract, hepatobiliary system, and pancreas. Authors are encouraged to submit manuscripts dealing with growth and development, digestion, secretion, absorption, metabolism, and motility relative to these organs, as well as research reports dealing with immune and inflammatory processes and with neural, endocrine, and circulatory control mechanisms that affect these organs. Reports of research utilizing molecular biological, cell biological, immunological, biochemical, and morphological approaches that contribute to knowledge of normal physiology or pathophysiology of these organs are especially welcomed. Research ranging from molecular and cellular events to whole animal studies and translational studies in human samples is appropriate.

The American Journal of Physiology - Heart and Circulatory Physiology publishes original investigations on the physiology of the heart, blood vessels, and lymphatics, including experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact animal to the cellular, subcellular, and molecular levels. It embraces new descriptions of these functions and of their control systems, as well as their bases in biochemistry, biophysics, genetics, and cell biology. Preference is given to research that provides significant new insights into the mechanisms that determine the performance of the normal and abnormal heart and circulation.

The American Journal of Physiology - Lung Cellular and Molecular Physiology publishes original research covering the broad scope of molecular, cellular, and integrative aspects of normal and abnormal function of cells and components of the respiratory system. Areas of interest include conducting airways, pulmonary circulation, lung endothelial and epithelial cells, the pleura, neuroendocrine and immunologic cells in the lung, neural cells involved in control of breathing, and cells of the diaphragm and thoracic muscles. The processes to be covered in the Journal include gas-exchange, metabolic control at the cellular level, intracellular signaling, gene expression, genomics, macromolecules and their turnover, cell-cell and cell-matrix interactions, cell motility, secretory mechanisms, membrane function, surfactant, matrix components, mucus and lining materials, lung defenses, macrophage function, transport of salt, water and protein, development and differentiation of the respiratory system, and response to the environment. Reports of research using innovative approaches in cell and organ physiology, molecular and cellular biology, molecular genetics, genomics including animal models of integrative function, biochemistry, biophysics, and morphology, are welcome. The Journal also encourages submission of original manuscripts in the field of translational physiology, an area of research that bridges the gap between basic lung, cellular, and molecular physiology and patient care. Manuscripts in this area may transfer clinical insights into hypotheses that can be tested and validated in the basic research laboratory, or they may transfer knowledge gained from basic research to human pathophysiology and to improved methods of treating or preventing disease.

The American Journal of Physiology - Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization, ranging from molecules to humans, including clinical investigations. Major areas of emphasis include regulation in genetically modified animals; model organisms and comparative functional genomics; development and tissue plasticity; neurohumoral control of circulation and hypertension; local control of circulation; cardiac and renal integration; thirst and volume, electrolyte homeostasis; appetite and obesity, and inflammation and cytokines.

The American Journal of Physiology - Renal Physiology publishes original manuscripts on a broad range of subjects relating to the kidney, urinary tract, and their respective cells and vasculature, as well as to the control of body fluid volume and composition. Studies may involve human or animal models, individual cell types, and isolated membrane systems. Authors are encouraged to submit reports on research using a wide range of approaches to the study of function in these systems, such as biochemistry, immunology, genetics, mathematical modeling, molecular biology, and physiological methodologies. Papers on the pathophysiological basis of disease processes of the kidney, urinary tract, and regulation of body fluids are also encouraged.

The American Journal of Physiology - Cell Physiology is dedicated to innovative approaches to the study of cell and molecular physiology. Contributions that use cellular and molecular approaches to shed light on mechanisms of physiological control at higher levels of organization also appear regularly. Manuscripts dealing with the structure and function of cell membranes, contractile systems, cellular organelles, and membrane channels, transporters, and pumps are encouraged. Studies dealing with integrated regulation of cellular function, including mechanisms of signal transduction, development, gene expression, cell-to-cell interactions, and the cell physiology of pathophysiological states, are also eagerly sought. Interdisciplinary studies that apply the approaches of biochemistry, biophysics, molecular biology, morphology, and immunology to the determination of new principles in cell physiology are especially.

The Journal of Applied Physiology publishes original papers that deal with diverse areas of research in applied physiology, especially those papers emphasizing adaptive and integrative mechanisms. Adaptive physiology includes 1) inherent adaptations such as those related to development, aging, and pathophysiological conditions and 2) adaptations to the external environment such as those occurring with exercise, microgravity, hypoxia, hypo- and hyperbaria, and hypo- and hyperthermic conditions. Integrative physiology includes 1) horizontal integration across organ systems and 2) vertical integration from molecule to cell to organ. In all areas of applied physiology, the use of cutting-edge techniques including molecular and cellular biology is strongly encouraged.The wide scientific span of the Journal rests on physiology as its keystone. However, the boundaries of physiology have enlarged as demarcations between concepts and techniques in the physiological, pharmacological, and biochemical sciences become increasingly blurred. Moreover, theoretical articles on research at any level of biological organization ranging from molecules to humans fall within the broad scope of the Journal. Papers dealing with topics in other basic sciences that impinge on physiology are also welcome.

Journal of Neurophysiology. This journal publishes original articles on the function of the nervous system. All levels of function are included, from the membrane and cell to systems and behavior. Experimental approaches include molecular neurobiology, cell culture and slice preparations, membrane physiology, developmental neurobiology, functional neuroanatomy, neurochemistry, neuropharmacology, systems electrophysiology, imaging and mapping techniques, and behavioral analysis. Experimental preparations may be invertebrate or vertebrate species, including humans. Theoretical studies are acceptable if they are tied closely to the interpretation of experimental data and elucidate principles of broad interest.

Physiological Genomics publishes the results of a wide variety of experimental and computational studies from human and model systems to link genes and pathways to physiological functions. The journal encourages the submission of research utilizing genomics, epigenomics, proteomics, metabolomics, and other systems approaches together with novel technologies linking genes to the function of complex biological pathways.

Physiological Reviews provides state of the art coverage of timely issues in the physiological and biomedical sciences. It appeals to physiologists, neuroscientists, cell biologists, biophysicists, and clinicians with special interest in pathophysiology. Topics are covered in a broad and comprehensive manner. These articles are very useful in teaching and research as they provide interesting, clearly written updates on important new developments.

Physiology publishes invited review articles written by leaders in their fields. These articles are peer reviewed and highlight major advances in the broadly defined field of physiology. The journal also publishes shorter articles that either present important emerging topics and technologies or differing points of view. Finally, the journal highlights and briefly summarizes some of the most exciting new papers in physiology. With a new format that is both exciting and attractive, the journal is a valuable tool for researchers, educators, and students.